Antoine has focused his career on patient care, education, advocacy, and research in the field of addiction, psychology of behavior change, and HIV. His areas of clinical and research expertise are substance use disorders (SUDs) and SUDs co-occurring with psychiatric disorders in adults and adolescents, tobacco cessation, psychology of behavior change, and motivational interviewing. He also has a substantial experience in training and disseminating evidence-based treatments for substance use disorders (SUDs), motivational interviewing to practitioners across disciplines in medical and psychiatric settings on local, national, and international levels. He has a well-established record in conducting multisite clinical trials as the PI, Co-PI and Co-I on NIAAA; NIMH; HRSA; SAMHSA; NIDA, NHLBI, AFSP, and industry sponsored grants. In recognition for his dedication to education and mentoring, Antoine has been the recipient of multiple teaching awards including the Leonard Tow Humanism in Medicine Award, the Charles Watson Teaching Award, and the Donald Fraley Award for Medical Student Mentoring, recognizing him for the qualities of a masterful clinician, academician, educator, mentor, contributor to the medical school community and the community at large. He currently serves as the Vice Chair of Pittsburgh HIV Commission and member of the Physician Workgroup on medical marijuana at the PA Department of Health. He also served as a member of the Opioid Addiction Task Force (established by U.S. District Attorney in Allegheny County) and The University of Pittsburgh Opioid Task Force. His publications include research papers, clinical writings, patients and family educational materials, and academic books.